Ambulance volunteers dealt with “four potential peak incidents” in Manchester city center last weekend.
It is not known whether the patients helped tested positive for substances commonly used to augment drinks, the St. John Ambulance said.
The charity issued a warning on the peak before Halloween weekend.
Volunteers were stationed on Sackville Street in Manchester’s gay village Friday and Saturday night as part of their usual weekly patrol to help clubbers in need of help.
But the service has encouraged Halloween revelers to be extra vigilant following the increase in the number of people being spiked across the UK.
A spokesperson said: “The St. John Ambulance (NTE) Nighttime Economy Support Services provide medical care and support to help keep people safe and healthy.
“Teams of rescuers and experienced healthcare professionals can also point out the services involved, including sending people to hospital if necessary, and arrange to ensure that those who are slightly injured or whose wear and tear is worse go home safe.
“If you or others are not feeling well, let the bar and door staff know who can call for medical assistance where they can contact the NTE service.
The Manchester Night Time Economy (NTE) Village service is an open, inclusive and supportive service providing non-judgmental assistance to users of the service.
“We are LGBTQ + friendly, aware of the challenges people may face, and are highly motivated to provide help and support to the community.
“We will support the city’s nightlife economy and take the pressure off NHS services by providing first aid and medical treatment on site, where possible.”
Following the weekend patrol, St. John Ambulance confirmed that “four potential peak incidents” were presented to the service over the weekend.
They pointed out that this was the total number presented to the team and that volunteers would not be able to “confirm or test related substances”.
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The charity has already warned of the main telltale signs of a spike, such as loss of balance, fatigue, decreased inhibitions, visual problems, confusion and vomiting.
He also encouraged club goers to stay with friends, never leave drinks unattended, and don’t accept drinks they don’t see being poured into the bar.
Almost 200 reports of doping of drinks and 56 injection peak reports have been made to British police forces over the past two months.
A Greater Manchester hospital saw ten patients walk through its doors last weekend who all had symptoms suggesting they may have been doped, according to the MEN.
Police in Manchester are investigating after three girls fell ill at Ark nightclub on Deansgate Locks in September.
While a series of young women have come forward to say their drinks have been spiked in Fallowfield and downtown.
Hundreds of people demonstrated in Manchester city center last week in response to the spate of reports of female drink and injection consumption.
People across the UK boycotted the clubs on Wednesday night following the reports.
42nd Street and The Venue nightclubs in Manchester city center have closed in solidarity with the boycott.
Warehouse Project boss Sacha Lord attended the event with Mayor Andy Burnham.
Lord, who is also a night economic adviser to the mayor – a introduces testing at WHP in response to worrying rise in nationwide reporting .
Clubbers who fear they may have been drugged with GHB, GBL or Rohypnol were tested by superclub medics last weekend under a new program, which will remain in place during upcoming events.
None have tested positive, Lord said.